Renal Disease And Cell Therapy
Being diagnosed with Renal Disease (RD) means one’s kidney is destroyed and cannot filter blood as expected.
In turn, there is build up of waste in the body, leading to a condition like heart disease.
The main causes of Chronic Kidney Disease are diabetes and high blood pressure, making its overall prevalence in the whole population to be at 14%.
For instance, in the United States, more than 661,000 of the inhabitants suffer from renal diseases, with 193,000 people functioning with a kidney transplant, while 468,000 are on dialysis.
The early stages of kidney disease can go undetected since it has no symptoms.
The thought of being diagnosed with kidney disease is severe because:
• Having Cardiovascular Disease along with Diabetes increases the risk of death in an individual suffering from kidney disease.
• Patient awareness is less than 10% for those with stages 1 to 3 of chronic kidney disease.
• Women are at a higher risk of getting stages 1 to 4 of chronic kidney disease as compared to men.
• Annually, kidney disease kills more people compared to any other illness.
Related Article – Chronic Kidney Disease : Are You At Risk?
> Cell Therapy For CKD
Could Cell Therapy Help With Renal Disease?
Recently, there have been massive steps towards restoring normal, damaged kidneys in AKI (acute kidney injury) and CKD (chronic kidney diseases), in preclinical models in cell-based therapy.
Considerable use of new cells has shown the usability of cell infusion and amelioration of renal utility. Although there have been successful attempts to treat renal diseases therapeutically, there are several things to consider.
When the renal diseases advance to higher levels, a kidney transplant is the only remedy. However, kidney transplantation faces the challenge of immune rejection.
Cell Therapy has proven to alter the effects of this condition, as it demonstrates improvement of renal functions and feasibility of cell infusion. Using cell therapy for treating renal dysfunction is the alternative solution since it is proven, safe and effective.
What Is Renal Disease?
Renal disease is where the kidneys lose their functions progressively over a period.
It is one of the leading causes of morbidity and mortality in developed countries, and it affects around 11% of the population. It does not have any cure, but one’s life can be prolonged through dialysis or renal transplantation.
Most of the kidney diseases attack the nephrons that are used as filtering units in the kidneys, causing poor filtering of blood. For instance, people who have diabetes are at a higher risk since their body cannot break down sugar properly.
Some of the other causes of RD include:
• Congenital abnormalities
• Vesicoureteral reflux when urine flows into your kidneys
• Glomerulonephritis, which is an inflammation of your kidney filters usually called glomeruli.
• Long-term blockage of the urinary tract either by an enlarged prostate, kidney stones, or a specific type of cancer.
Once a kidney is impaired, it becomes incapable of rendering its expected functions and could increase the potassium levels in your body leading to a heart condition.
Another issue may be high blood pressure, swelling of the legs and arms, or pulmonary edema. Men are likely to experience reduced fertility, decreased sex drive, and erectile dysfunction.
To slow down the progression of the disease, it is mandatory to monitor your weight as fluid retention can dramatically lead to weight changes. Another way of leading a healthy lifestyle is by decreasing protein consumption while increasing your caloric intake.
By limiting foods like avocados, spinach, chocolate, oranges, nuts and peanuts, tomatoes, and bananas, your potassium or sodium consumption is lowered.
The work of kidneys is typically filtering excess fluids and body wastes in the blood and then excreted through urine.
Dangerous levels of fluid, wastes and electrolytes can build up in your body if the kidneys do not do their work.
This leads to numerous changes in your body. They include:
• Reduced volume of urine
• Decreased mental sharpness
• Swelling of some body parts like the face, feet, and ankles
• Pain in chest area due to accumulated fluids around the heart
• Short breaths due to the presence of excess fluids in the lungs
• Muscles paralysis
• Difficulties in sleeping
• Loss of appetite
• Uncommon weakness and fatigue
These symptoms, however, might not show during the early stages of the kidney disease. This is because kidneys are adaptable and can hide a lost function.
However, experts advise patients that if they experience these symptoms, they should try a test for other diseases because other illnesses can cause these symptoms.
Below are some of the risk factors that are likely to cause renal disease:
• The kidney diseases after a kidney transplant
• High blood pressure
• If a person has diabetes and has poor sugar control
• Older age
• Male sex
• The conditions that affect kidney structures that filter fluids and water materials, majorly the glomeruli.
• African –American descent
• Tobacco use
• The effects of kidney damage in the body of the patient
Making frequent hospital visits is essential as the doctor may monitor the kidney function and your blood pressure. In case signs and symptoms of kidney disease emanate, ensure to make an appointment with your doctor.
Further Reading – Quality Articles From Third Party Websites
-  Mayo Clinic
-  NCBI – National Center for Biotechnology Information
-  NIH – National Institute of Health
-  Healthline
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