Peripheral Artery Disease – Innovative Treatment With Cell Therapy
Cell Therapy For Peripheral Artery Disease
Peripheral Artery Disease (PAD) is a progressive disease where lack of enough blood flow leads to narrowing and spasm of blood vessels outside the brain and heart.
PAD usually occurs in the veins and arteries translating to fatigue and pain often in the feet and legs.
The condition worsens when indulging in physical exercises and improves with rest.
Could Cell Therapy Help With Peripheral Artery Disease?
A standard case for the treatment of this chronic disease is endovascular revascularization or surgery.
Due to unfavorable vascular involvement or high operative risk, around 30% of patients are not candidates for this intervention.
As a result, new strategies are vital in providing these patients with a viable treatment.
Cell Therapy has been identified as the best therapeutic option to administer angiogenesis. This discovery has made clinical researchers find the feasibility of new cells in individuals with coronary and peripheral artery diseases.
Angiogenesis is the physiological process through which new blood vessels form from pre-existing vessels. In precise usage this is distinct from vasculogenesis, which is the “de novo formation” of endothelial cells from mesoderm cell precursors, and from neovascularization.
The results were surprising as it showed an improvement in oxygen pressure and ankle-brachial index (ABI). There was a significant reduction in chances of amputation and pain was also reduced.
> Case Studies: Cell Therapy – A Retrospective Study 2017
Peripheral Artery Disease Symptoms
Most individuals who have been affected by PAD usually start by experiencing discomforts like cramping and fatigue in the feet or calf area.
The condition gets worse with any physical activity due to lack of enough blood flowing to the lower body area.
While some patients experience mild to no symptoms, others experience pain while resting and non-healing wounds, skin temperature changes and pulse changes.
So far, the most common symptom of PAD is claudication – a lower limb muscle pain that is usually experienced when walking for long distances or in fast motion)
Appropriate diagnosis is vital if you suspect you may be suffering from peripheral artery disease.
There are numerous factors associated with peripheral artery disease, and they include:
- Kidney Diseases on hemodialysis
- High blood pressure
- A family history of High Cholesterol
- Heart Disease
- History of Cerebrovascular Disease or Stroke
- Abnormal levels of cholesterol
- Individuals above the age of 50
Poor life style choices can also be a contributing factor for PAD, and they include drug use, smoking, poor eating habits, and not engaging in enough physical exercises.
What Causes PAD ?
The known cause of PAD is mostly thromboangiitis obliterans (TAO) and atherosclerosis obliterans (ASO).
Sometimes vessels which supply blood to the kidneys, stomach, and arms are also affected, leading to blood flow issues.
Since fatty build-up occurs in all the arteries in the human body, patients are likely to suffer a heart attack.
Peripheral artery disease is a highly prevalent condition with severe mortality and morbidity.
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