Cell Therapy: An Old And Successful Therapy | Villa Medica
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Cell Therapy: An Old And Successful Therapy

The Lack of Knowledge About an Old And Successful Therapy

Summary

In view of the fact that Cell Therapy was discovered in 1931 and has been used since then, it is still up against a lot of resistance from conventional medical practitioners. They do not see the fact that it has virtually no side effects and overlook the huge successes which have helped many for whom there was no other “conventional” treatment available, and who were helped or cured with cell therapy.

Looking at the amount of research that is going into stem cells and cell research, it is surprising that none of these scientists wonder where the success of cell therapy comes from. I believe that this therapy will retain its value, not just to treat illnesses, but also as an Anti-Aging treatment to meet people’s wish for Rejuvenation.

The Origin of Cell Therapy

On April 1, 1931, Prof. Dr. Niehans discovered the cellular therapy. Having successfully transplanted xenogenic (derived from animals) hormonal glands since 1927, he suddenly found himself confronted with a surgical injury to the parathyroid gland in 1931.

The patient was suffering from such extreme muscular cramps, that they feared for her life. Prof. Niehans was consulted and that was the first time that cell therapy was used, to great success. This was due to the fact that for the first time the entire organ had been transplanted, which had not been possible before.

According to the records, this patient lived on for more than 25 years after the transplant. As a result of this, Cell Therapy was used as a Rejuvenating Therapy, particularly after the 2nd World War, to be understood as a therapy for the loss of youth due to the war.

Villa Medica - Cell Therapy: Paul Niehans

“ What I am striving after is not only to give more years to your life but also to give more life to your years. ” – Prof. Dr. Paul Niehans

There were a number of cell therapists at the time of and after Prof. Niehans, in the early 50s, Siegfried Block established his sanatorium for cellular therapies. While he concentrated on the rejuvenating effects of this therapy, Janson-Mueller discovered that excellent results could be achieved in Multiple Sclerosis patients.

Hofecker, Gali and a number of colleagues from all over Germany were also pioneers in this field. It was Alexander Gali who developed a therapy against osteoarthritis out of the cell therapy, in which he injected cartilaginous tissue in or on the damaged joints with excellent results. I will go into greater detail in the last paragraph of this report.

Patients’ Requirements For Cell Therapy

Basically anybody seeking regeneration and anti-aging can use this therapy.

On top of that, Cell Therapy can be used for a number of illnesses, which I will go into more detail about later. There are however requirements that the patients must meet.

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Patients with acute infections cannot be treated. Furthermore, illnesses which can only be treated through an operation such as arterial occlusion or coronary heart disease, as well as decompensation of the lungs, heart, kidney and cerebral sclerosis where the patient is already in need of care and bed-ridden.

It is not possible to treat obese patients if the injection of the solution cannot be done intramuscularly – not even with a 100mm needle.

What Can Cell Therapy Be Used For ?

Cell Therapy can be used for many different illnesses and only the most significant ones have been listed here:

  • Geriatrics
    Premature aging, exhaustion, diminishing vigour, sleeping problems, lack of concentration, forgetfulness, anxiety, depression
  • Chronic Functional or Degenerative Organic Illnesses
    Kidney or digestive problems which impair the stomach, gallbladder or pancreas, chronic constipation, chronic liver problems, intervertebral, spinal and joint problems
  • Heart & Circulatory Problems
    After Heart Attacks and Strokes, Circulatory Problems of the Brain, Coronary Arteries, extremities, dizziness, Tinnitus and Vascular Calcification
  • Allergies
    Hay Fever, Urticaria, Allergic Skin Reactions, and Asthma
  • General Immune Deficiencies
    Multiple Sclerosis, Amyotrophic Lateral Sclerosis(ALS), Morbus Alzheimer
  • Vegetative & Neurological Disorders
    Depression, Psychosis etc.
  • Hormonal Disorders
    Sexual Dysfunctions in men and women, Infertility, Menstrual Disorders, Menopausal Disorders, Growth Disorder, Obesity, Diabetes Mellitus
  • Genetic & Development Dysfunctions In Infants And Children
    Down’s Syndrome, Infantile Brain Damage, brain damage due to infections and vaccinations, accidents and poisoning.
  • Additional Treatment Against Cancer
    Treatment with umbilical tissue, Adrenal Gland, Thyroid and others to stimulate the Immune System.

Effects Of The Therapy

Prof. Dr. Kment from Vienna provided evidence of revitalisation and “… a younger biological age” through animal experiments. It was quickly proven through isotopic tests that the various xenogenic tissue and organs that were implanted attach themselves to the patient’s corresponding organs.

Villa Medica - 3 Steps Of Cell Therapy: Protect, Repair & Regenerate

3 Steps Of Cell Therapy: Protect existing cells, Repair damaged cells and tissues & Regenerate – to promote and stimulate cell regeneration process

Habers describes this as an enhancement of the recipient organ. He found that there was an increased enhancement in the damaged tissue of up to 4 times. On the 15th August 1987 there was an extract of the interview in the Hamburger Abendblatt with Prof. Landsberger:

…The Heidelberg university lecturer and morphologist Prof. Dr. Albert Landsberger is certain the injected animal protein molecules have an affinity with the mesenchym organ, which means that they are coded to follow the blood stream to the desired organ. Landsberger compares this to the way that hormones find their way within the hormonal system which begins in the brain’s hypophyse, the extracts are then transported to the glands in which they are to become effective.

Gunter Blobel’s scientific research of discovering “the built in signals of the proteins which enables them to be transported to and localise the cell” confirms Haber’s tests and Landsberger’s explanation. Gunter Blobel was given the Nobel Prize for medical research in 1999.

We can sum it up as follows
When implanting xenogenic tissue it is not type specific but organ specific, so that there is no indication of a dubious ethical human embryonic tissue, as xenogenic tissue has the same organ specifications and therefore the same effect.

 


Related Article – Case Studies: Cell Therapy – A Retrospective Study 2017
> Read the full article here


 

Conditions For Therapy

A Cell Therapy is only done on inpatients in Villa Medica private clinic in Edenkoben, the last to use this method in Germany.

The therapy lasts four days. The patient has to arrive a day before the therapy begins, the medical history is established, then the physical examination and the necessary laboratory tests.

Live Cell Therapy is Natural, Safe And Effective

If there is no contraindication, therapy begins at around 10.30 am the next day. The patient then has bed rest for the next 36 hours. The afternoon thereafter he/she can move around within the clinic and go home the next day.

I refuse to treat outpatients, as do all other doctors in our associations. The injection of the different cell solutions are done in one.

An injection takes around 2 minutes. It is wrong to inject on different days with a stay of no more than two hours, as is advertised by homeopaths, and which is not permitted.

Cell Therapy And Arthritis

As I have already mentioned, Alexander Gali had been developing his arthritis therapy from cellular therapy. Gali reported on this therapy at the IXth Congress for Cellular Therapy in 1982 for the first time in the talk “Experiences with intra-articularly injecting foetal tissue”

He summarised his success as follows:

The big success of this therapy is easier movement, higher resilience and an optimum improvement with impediments”.

When I took the clinic on from Dr Gali 20 years ago, I also took on the Arthritis Therapy based on cell therapy. Foetal cartilage and joint tissue are used for this, which is then made into a cell solution injected into or on the affected joint. In his time, Gali only treated shoulders, hips and knees. After I had taken over the clinic, I saw the success of the treatment and went on to treat all joints, including the spine.

 


Related Article – Case Studies: A Retrospective Arthritis Case Study 2017
> Read the full article here


 

Therapeutic Incidents, Allergies And Side Effects

One of the most frequently asked questions with regards to cell therapy is whether it can cause an anaphylactic shock or allergy. This question is asked as the doctrine does not permit the treatment of injected foetal, xenogenic cells and this false understanding is constantly repeated like a mantra.

On 23rd March 1993, Prof. Dr. med. Vet. Claus Hammer from the Institute for research Surgery at the Clinic in Grosshadern, Munich wrote, on behalf of the Association of Doctor for Cell Therapy, the following about “Therapeutic use of injecting stem cells in human beings” :

In contrast the rare occurrence of side effect from cell therapy, there are extensive observations which show that these have not occurred. Injecting live cells into the human organism is comparable with a xenogenic organ transplant. In experiments, but also in clinics, entire organs such as heart, liver, kidneys as well as cell groups such as islets, heart valves, arteries and skin transplanted. The former are directly applied to the patient, the latter via a secondary neovascularisation to the recipient.”

“Test on patients who have undergone cell therapy show that the patients already had antibodies against sheep, dog, pig and rat erythrocytes prior to the injection. Despite this, the first administration thereof did not cause any adverse reaction, just as the first contact with a butcher’s knife didn’t.”

Mechanism

The lowest titre is against sheep (1:4/16), the highest against rats (1:512). The antibodies titres rise differently but significantly after the application. The treatment with Di-thio-treitol shows that primary antibodies, mainly however IGMs also belong to the IGG group later on. Patients, who had been treated up to 6 times, had a very high titre of >1052. There do not appear to be any serious side effect of cell therapy. There are more active lymphocytes and monocytes in the peripheral blood of the patient, however they do not achieve a pathological level as is common in immune reactions to virus or bacteria. The b-cells are slightly higher. There was no significant change in the t-subpopulation.

Villa Medica - Cell Therapy Explained - Infographic

Cell Therapy is an old treatment modality which involves implantation of living cells for treatment of diseases.

It can therefore be said that we use foetal material which has not yet been genetically imprinted with immunological information.

  1. No one has ever had an anaphylactic shock with an intramuscular injection
    In the last 20 years, I have only ever experienced this reaction twice, the reason being that it had not been applied to the strict intramuscular guidelines. In both cases the patients were obese woman and it was not possible to inject properly despite using a 100mm needle, as there was too much fatty tissue on the rump. This probably led to an intravascular inflow of the solution. Inspite of this the situation was under control quickly. This is why we no longer treat extremely obese patients.
  2. Delayed allergic reactions can occur, but these are usually in the contact area. This affects roughly 1% of the 50,000 patients that have been treated in the last 20 years.

It has to be said that placenta tissue causes more reactions than other, which is why it is no longer used in the private clinic Villa Medica in Edenkoben, Germany. The reason for this is that in the placenta tissue there are adult and embryonic cells, the adult cells being the cause of an allergic reaction.

Further Development With And Through The Therapy

Prof. Dr. Franz Schmid was another of these pioneers. However in agreement with Prof. Dr. Paul Niehans, he changed the therapy in the beginning of the 50 to lyophilisate, apparently to safeguard the therapy – this was the official reason – and to be able to sell these products to doctors and homeopaths.

During a discussion with Prof. Franz Schmid, Prof. Albert Landsberger, Prof. Dominik Weibel, the president of the Swiss Association for cell therapy, and myself in the 90s, Prof. Schmid insisted on this, despite the fact that at that time the strict guidelines on the extraction of sterile cellular therapy products and the health check for donor animals had been passed in 1978 and been used in cell therapy clinics since then.

Villa Medica - The Benefit of Live Cell Therapy

It is believed that the benefit of Live Cell Therapy is : 70% due to the direct stimulation of regeneration, and 30% due to transplantation of new cells

His own company “Cibila” had been shut down on the basis of the ban of lyophilisates in 1987. The withdrawal of these products from the market was ordered by the German health authority in August 1987 and was applicable to the lyophilisates as well as frozen cell products from the company Dr. Miller in Hamburg amongst others. Till then there had been no research or studies done on these products.

As these products (lyophilisate and frozen cells) were being sold as live cells, there was a legal dispute as to what exactly “live cells” and “live cell therapy” was exactly and how it is defined. This was clarified at the High Court in Dusseldorf on 2nd June 1977, case no. 2U41/7512U462-74 in which the following legally binding definition was given.

Animal tissue extracted from young animals or foetuses  which is taken from the animal which is raised close to the clinic and has been serologically tested, and given as an injection to the patient within 20 minutes of extraction. Frozen or dried cells are not immediately used but frozen or lyophilisized.

Cell Therapy is a highly uncomplicated therapy with very few side effects. However, the therapist must have extensive knowledge and experience with it. As in the past these products (lyophilisates and frozen cells) were widely available, there were incidents which led the German health authorities to withdraw these products.

The Ruling of the Federal Constitutional Court

As the German Ministry of Health did not make a difference between the readymade products and the freshly extracted cells due to a lack of in-depth knowledge, the German health authorities wanted to ban live cell therapy. Due to Germany’s freedom of applied therapies, this was and is not possible.

The following ruling was passed by the Federal Constitutional Court after a legal dispute regarding the ban of live cell therapy, instigated by myself and other colleagues, on the 16th February 2000:

Live Cell Therapy is mainly the use of live animal cells which are injected into the patient with the purpose of achieving a revitalising effect. These cells are generally extracted from sheep’s foetuses. The female donor animals are from closed herds, this is done to prevent the risk of contagious diseases.”

It goes on to say: “The term of regarding the use of these products does not include methods used by doctors which means giving patients products which they made themselves and which are used immediately.

This definition in this ruling clearly shows that frozen cells, lyophilisates, cytoplasm therapy (VitOrgan®), therapies with cell particles (Regeneresen®) and organ extraction therapy including thymus therapy are not live cell therapies.

The main difference is in-house production of the live cells and the immediate use on ones own patients. This is therapy and not treatment with commercial products. All other products are therefore medications which require a licence according to the definition of the German pharmaceuticals law.


Related Article – Cell Therapy History: The Foundation Of Cell Therapy
> Read the full article here


 

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Further Reading – Quality Articles About Cell Therapy

  1. Niehans, P. Introduction to Cell Therapy. Pageant Books, Inc, New York, 1960.
  2. Lipton, B. The Biology of Belief. Hay House Inc., 2005.
  3. Schmid, F., Stein, J. Cell Research and Cell Therapy, Ott Publishers, Thun, Switzerland, 1967.
  4. Molnar, E. M. Textbook of Stem Cell Transplantation. Medical and Engineering Publishers, 2006.
  5. InSoo Kim, D.D.S., Ph.D. A brief overview of cell therapy and its product. Published online 2013 Oct 22.
  6. Gage FH. Cell therapy. Nature. 1998;392(6679 Suppl):18–24
  7. Nathalie Hirt-Burri, Albert-Adrien Ramelet, Wassim Raffoul, Anthony de Buys Roessingh, Corinne Scaletta, Dominique Pioletti, Lee Ann Applegate. Biologicals and Fetal Cell Therapy for Wound and Scar Management ISRN Dermatol. 2011; 2011: 549870. Published online 2011 May 18. doi: 10.5402/2011/549870

 

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