Villa Medica

Liver Diseases : Are We Close To A Cure?

Liver Diseases: Prevention Is Always Better Than Cure

Chronic Liver Diseases is one of the leading top 10 biggest killers on the planet. Over time substantial damages to the liver would reduce the liver’s capacity for self-repair tremendously, escalating it into liver failure, a life-threatening condition. The only treatment deem plausible today is a liver transplant.

Villa Medica - Liver Diseases - Facts and Risk Factors Infographic

Liver Diseases – Facts & Risk Factors: Alcoholic Liver Disease was responsible for 70% of alcohol specific deaths

Although the liver can self regenerate, there are no warning signs for early detection if it malfunctions. Once chronic liver disease is diagnosed and transitioned into the final stage or acute liver failure, treatment options become sparse. Unlike kidney dialysis, there is no “liver dialysis” available to support the rehabilitation of the liver function.

Liver transplantation is prevalent as the only effective treatment for liver failure today. The downside to this is that it comes with many limitations, including the risk of rejection, risks associated with surgery, and a shortage of organ donors. The donor organ waiting list is endless and sadly many end-stage patients could not wait long enough and succumb to the liver diseases.

This constant demand for donor organs that always exceeds the supply, made it critical and necessary for other therapeutic alternatives.

A Better Alternative For Liver Transplantation

In response to this dilemma, Cell Therapies have emerged as a promising tool in the treatment of liver failure. Of all the organs, the liver is especially responsive to this type of therapy given its innate capacity for endogenous regeneration and repair.

The treatment of Chronic Liver Disease and Cirrhosis predominantly focuses on repairing the scarred liver structure, as well as improving homeostasis and liver function.

The evolution of Regenerative Medicine has propelled a shift towards ascertaining the therapeutic and regenerative potential of Cell Therapy as a better alternative for liver transplantation. This holds great promise for the treatment of liver disease or at the very least decrease waitlist mortality rates.

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Examples of Liver Diseases that have been successfully treated with Cell Therapies at medical centers around the world consist of Acute Liver Failure (ALF), Acute-on-Chronic Liver Failure, and inherited Metabolic Liver Diseases. It also potentially encompassed a wider application in other liver diseases as well, including non-inherited liver diseases, and in improving the success of liver transplantation.

What Are Liver Diseases?

Liver diseases comprise a vast range of complex conditions that affect the liver, disabling it from its optimal functions. The liver is the largest internal organ in your body with multifunctional roles in digestion, managing blood sugar, blood clotting factors for healing, amino acids production, red blood cell growth, fat and cholesterol transfer and the removal of toxic waste exposure.

Villa Medica, Liver Diseases - Stages of liver damage Infographic

Liver Diseases – Causes and Stages of liver damage: Liver disease is any disturbance of liver function that causes illness. Liver disease is a broad term that covers all the potential problems that cause the liver to fail to perform its designated functions.

Liver diseases degenerate and affect the liver cells, leading to abnormal and scarred liver tissue that inhibits healthy liver function. It can lead to cirrhosis and liver failure over time. Cirrhosis is the permanent scarring of the liver. Acute Liver Failure is a life threatening condition and deemed non-reversible.

Associated complications include increased risk of bleeding and infection, malnutrition and weight loss, decreased cognitive function over time and an increased risk of cancer. Liver diseases are a costly and heavy toll in terms of medical bills, human suffering, reduced productivity and the decreased in the quality of life.

Regenerative Medicine And Liver Diseases

However, with the advent of Regenerative Medicine, Cell Therapy has been proven effective in managing Liver Diseases. Nevertheless, reinforcing healthy lifestyle modification can make a difference in helping to shift from a condition of day-to-day survival to one of a better quality of life.

Eat healthy, stay healthy, have a good healthy regime to prevent and mitigate all the possibilities towards this disease. Avoid alcohol or at least consume it moderately. Excessive alcohol consumption, unhealthy diet, obesity and drugs are among the main risk factors for these killer diseases.


Further Reading – Quality Articles From Third Party Websites

  1. National Health Service (NHS)
  2. U.S. National Library of Medicine


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